EVALUATION OF GLUCOSE TOLERANCE IN OBESE RATS TREATED WITH Citrus bergamia FRUIT EXTRACT

  • Gustavo Volpato Universidade Federal de Mato Grosso
  • Débora Damasceno Unesp
  • Maria Eduarda Gomes Unesp
  • Isabela Silva Unesp
  • Camila Camacho Unesp
  • Maysa Souza Unesp
  • Franciane Gallego Unesp
  • Vinicius Barco Unesp
  • Taynara Vieira Unesp
  • Núbia Grandini Unesp
Palavras-chave: obesity, glucose intolerance, bergamot, rodent.

Resumo

The objective was to evaluate the role of C. bergamia aqueous fruit extract (BFE) in the glucose tolerance of obese rats. Male Wistar rats with obesity induced by a high-fat and high-sugar diet (HSF) were used for 30 post-weaning weeks. In week 20, the BFE treatment was started, lasting ten weeks. At the end of the treatment, the animals were subjected to an Oral Glucose Tolerance Test (OGTT) to determine  the Area Under the Curve (AUC), were anesthetized, and killed for blood collection. At time points 0 (fasting) and 120 minutes, and the AUC, the glycemia was higher in the obese groups (HSF and HSF+BFE) than C and C+BFE groups. However, the AUC was reduced in the HSF+BFE group than HSF group, confirming a lower circulating glucose level. Therefore, BFE treatment effectively improved the glucose tolerance of the obese rats.

Publicado
2024-12-16
Seção
Ciências da Saúde